Inhibition of HMGB1 by deep ocean water attenuates endotoxin-induced sepsis
- 標題
- Inhibition of HMGB1 by deep ocean water attenuates endotoxin-induced sepsis
- 作者
- Ko-ichi Kawahara, Teruto Hashiguchi, Takashi Ito, Kiyoshi Kikuchi, Yoko Morimoto, Toshiaki Shimizu, Yoko Oyama, Kazunori Takenouchi, Shin-ichiro Arimura, Noboru Taniguchi, Ikuro Maruyama, Masahiro Iwata, Salunya Tancharoen, Masako Unoshima, Hideo Iwasaka
- 文件屬性
- 國外期刊
- 知識分類
- 醫療保健
- 出版年
- 2007
- 刊名
- Medical Hypotheses
- 點閱數
- 2686
摘要
Recent studies have clarified the mechanism of development and progression in sepsis [1]. However, the sepsis remains a serious problem in critically ill patients. The mortality in patients with sepsis is caused by bacterial endotoxin. Endotoxin stimulates macrophages/monocytes to release high mobility group box 1 (HMGB1), a chromatin protein with a cytokine function. The extracellular HMGB1 acts as a pro-inflammatory cytokine following releases from necrotic cells or macrophages activated by tumor necrosis factor (TNF)-α or interferon (IFN)-γ through the toll-like receptor -2 or -4 and receptor for advanced glycation end-products (RAGE), suggesting “cytokine loops” in inflammatory disease such as rheumatoid arthritis (RA) and atherosclerosis [2,3].