One-pot isomerization of aldo-disaccharides to keto-disaccharides in deep sea water under sub-critical conditions
- 標題
- One-pot isomerization of aldo-disaccharides to keto-disaccharides in deep sea water under sub-critical conditions
- 作者
- Aditya Kulkarni, Makoto Ogata, Takeshi Sako, Taichi Usui
- 文件屬性
- 國外期刊
- 知識分類
- 基礎研究
- 出版年
- 2012
- 刊名
- Tetrahedron Letters
- 關鍵字
- Aldo-disaccharide; Keto-disaccharide; Sub-critical water; Sea water; Lactulose; Isomerization
- 點閱數
- 2436
摘要
A novel and facile one-pot isomerization of aldo-disaccharides to keto-disaccharides is achieved by making use of deep sea water in sub-critical conditions. The resulting keto-disaccharides having pharmaceutical and food applications were obtained in modest yields of about 30–32% at the optimum reaction conditions (temperature: 180 °C, reaction time: 5 min). Detailed investigation of all major ions in deep sea water revealed that bicarbonate ions play a key role as a catalyst in this isomerization reaction.